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Articles from 2010 In June


Study: Botox may slow emotional communication

Article-Study: Botox may slow emotional communication

Madison, Wis. — Results of a recent study suggest that those who undergo cosmetic Botox (onabotulinumtoxinA, Allergan) treatment may be risking the ability to communicate emotions through facial expressions, the Los Angeles Times reports.

Past research indicates that facial expressions not only reflect our emotions, but appear to send crucial feedback to the brain — and that without this feedback, one’s ability to understand and be understood might be lessened. Botox is known to block facial nerve impulses.

In the recent study, headed by David Havas, a psychology graduate student at the University of Wisconsin-Madison, 40 women waiting to receive first-time Botox injections were asked to read a series of 60 sentences on a computer, pressing a key when they understood each sentence. Two weeks later, when the Botox treatment’s paralyzing effect was at its height, the same women took a similar test using a new set of questions.

After treatment, participants were slower to understand sentences conveying sadness or anger than they had been before treatment. According to Havas, the results indicate that our own facial expressions help the brain to make sense of the social world, and that when the face’s ability to provide feedback to the brain is hampered, so is our ability to understand and interpret emotions.

The Times quotes Havas as saying, “Our facial expressions reveal social context by mirroring expressions of those around us, giving us insight into their emotions, states of mind, and future actions,” and that the Botox study suggests that our facial expressions also guide how we interpret language.

Optimism not linked to higher surgery satisfaction

Article-Optimism not linked to higher surgery satisfaction

Palo Alto, Calif. — New research suggests that baseline pessimism and optimism are not associated with patient satisfaction with facial plastic surgery, and that plastic surgery patients being treated for depression are more satisfied with their procedure than patients not being treated for depression, HealthDay News reports.

Researchers led by Jill L. Hessler, M.D., of Premier Plastic Surgery, here, examined the answers of 51 facial plastic surgery patients who completed a survey on demographics and baseline levels of optimism/pessimism as well as a surgery-specific questionnaire shortly before and a few months after their surgery.

Investigators found that patients over the mean age of 53 were more satisfied with the results of their surgery than younger patients, and that those being treated for depression were more satisfied than those not being treated.

“Despite a priori hypotheses that patients treated for depression might be more pessimistic and rate their satisfaction lower than other patients,” the authors write in their conclusion, “patients treated for depression show a trend toward greater satisfaction from facial plastic surgical procedures than those not treated for depression.”

The study appears in the May/June issue of the Archives of Facial Plastic Surgery.

Mercury found in certain skin-whitening creams

Article-Mercury found in certain skin-whitening creams

Chicago — The Chicago Tribune reports that some skin-whitening creams contain toxic levels of mercury.

According to the news-broadcast transcript appearing on the Web site of Chicago’s WGN, the Tribune sent 50 skin-lightening creams to a lab for testing. Most were purchased in Chicago-area stores. The lab found that six creams contained amounts of mercury banned by federal law since 1990.

The six creams — Stillman’s Skin Bleach Cream, Top-Gel MCA Extra Pearl Cream, Crème Diana, Ling Ji Su, Luluajina, and Shabright Clear and Bright Formula — are manufactured in Lebanon, China, India, Pakistan and Taiwan, according to the Tribune. Some of the manufacturers said the products tested were counterfeit.

High-tech tanning devices heighten melanoma risk

Article-High-tech tanning devices heighten melanoma risk

Minneapolis — A new study shows that people who use high-speed/high-intensity indoor tanning beds run the highest risk of melanoma, HealthDay News reports.

Researchers at the University of Minnesota surveyed 1,167 subjects diagnosed with invasive cutaneous melanoma from 2004 to 2007, as well as a demographically matched control group of 1,101 subjects. The two groups were asked about their experience with indoor tanning equipment, type of equipment used, age of initiation, length of use, period of use, doses and any tanning-caused burns.

Among the melanoma group, 62.9 percent of subjects had used indoor tanning equipment compared with 51.1 percent in the control group. Among those who had used indoor tanning equipment even for a short time, there was a 74 percent increased risk of melanoma.

Risk odds were highest among those who had used high-pressure (UVA-emitting) tanning devices and high-speed/high-intensity (UVB-enhanced) devices than among those who used sunlamps or conventional tanning equipment.

There was a strong dose-response relationship between melanoma risk measured in total hours, sessions or years spent tanning.

“In a highly exposed population, frequent indoor tanning increased melanoma risk, regardless of age when indoor tanning began. Elevated risks were observed across devices,” the authors conclude.

Cosmetic Surgery Times, Digital Edition, June 2010

Article-Cosmetic Surgery Times, Digital Edition, June 2010

Ethnic patients seeking rhinoplasty may prefer to retain uniqueness of features

Article-Ethnic patients seeking rhinoplasty may prefer to retain uniqueness of features

Key iconKey Points

  • Many ethnic patients seeking rhinoplasty wish to preserve ethnic 'flavor' of the nose
  • Consider skin thickness, cartilage stiffness prior to rhinoplasty in ethnic patients
  • Using patients' own cartilage safer than silicone or other artificial implants, one surgeon says

Retaining the ethnic "flavor" of one's nose is a common goal among the vast majority of ethnic patients seeking rhinoplasty, according to surgeons who devote a significant portion of their practice to this procedure.

"There has been a fear among African-American, and, to a lesser degree, in Latino and even Asian patients, that if they wanted to change their features that this would signify that they weren't proud of who they were," says cosmetic surgeon Charles M. Boyd, M.D., who is in private practice in Birmingham, Mich., and New York. In ethnic patients who seek rhinoplasty, Dr. Boyd's goal is to de-emphasize the nose and draw attention to the eyes instead. "There are subtle things that we can do to make a change in the profile, in the definition of the nose, without changing their ethnicity, without intrinsically changing their appearance," Dr. Boyd says.


A black patient before (left) and after rhinoplasty. — (Photos credit: Steven Hopping, M.D.)
Washington cosmetic surgeon Steven B. Hopping, M.D., who lectures on ethnic rhinoplasty, also stresses that most patients want to retain their ethnicity. "Oftentimes, the typical patient is a woman who has inherited her father's nose and doesn't want to be quite that ethnic. She'd prefer something like their mother's or sister's nose," says Dr. Hopping, clinical professor of surgery, George Washington University, Washington.

A Middle Eastern patient before (left) and after rhinoplasty. — (Photos credit: Steven Hopping, M.D.)
Both Drs. Boyd and Hopping stress that communicating with patients to get a clear picture of their goals is the most important aspect of the entire procedure. "I use computer imaging and this is very helpful in pinpointing what patients are trying to achieve, and it enables them to see what's in my mind as well," Dr. Hopping says.

Dr. Boyd points out that some patients are really looking for a new nose, while others want subtle changes. "If the patient wants dramatic changes and the surgeon doesn't provide that, or similarly, if the patient wants subtle changes and the surgeon has completely changed the nose, the patient is not going to be happy," Dr. Boyd says. "So, you really need to communicate to share the same vision."

SURGICAL MANEUVERS As far as surgical strategy, skin thickness and cartilage stiffness are standard anatomic considerations of which surgeons should be cognizant with respect to ethnic rhinoplasty. "These are the two most important things to assess preoperatively, because if the patient has really thick skin and really poor cartilage support, then the surgeon has to pull out all the stops," Dr. Hopping says. "In cases like this, you have to de-fat the skin in order for the patient to be able to appreciate any of the changes or refinement that you introduce, and you're going to have to use some kind of graft — probably the patient's own cartilage in the tip to create some definition."

Thicker skin and poor cartilage support are common among African Americans, Middle Easterners and Asians, Dr. Hopping says. "Even though a lot of patients of these ethnic backgrounds want a smaller nose, they need to augment with their own cartilage," he says, adding that he believes using patients' own cartilage is much safer than using silicone or some other artificial material implant. "Even Asian patients — who tend to want to make their noses slightly larger — have generally poor cartilage support and have fairly thick skin. So we need to either put an implant in, or use the patient's own cartilage to provide some definition," he says.

WALKING A FINE LINE There's a fine line between de-fatting the skin enough to feature the refinements made, and thinning the skin too much. Dr. Boyd points out that one of the biggest mistakes that surgeons can make in performing rhinoplasty in thick-skinned patients is to overly thin the skin. "This is a concern in Southeast Asian, African-American and even some Latino noses. Surgeons feel a strong desire to thin the nose, and they do an open rhinoplasty and remove some of the tissue or the subcutaneous tissue below the skin. This can be done effectively in moderation, but the danger is in going to far," he says. "If it's an African-American patient who has relatively thick skin, I won't thin the skin so much. Instead, I'll use more cartilage to build up the tip, to build up the dorsum, and then the thinning will take care of itself," he says. "If you add enough structure to give the nose the proper projection, then you really don't need to thin the skin at all."

Middle Eastern patients' noses also have thick skin, but they have a distinct shape that includes a dorsum hump and a bit of tip ptosis as well. "Often, the tip needs to be augmented and the dorsum needs to be reduced," Dr. Boyd says.

Dr. Hopping, who often performs surgery in Dubai, United Arab Emirates, says, "In Dubai, they don't want an 'American nose.' There they like to keep the nose longer for a more natural look." He notes that this requires a pure reductive rhinoplasty. "We just have to be cognizant of not doing as much as we might typically do in the Western world because in Arab cultures, they often want to keep the nasal length," he says.

A distinction in black patients' noses, Dr. Hopping notes, is the width. "If you leave the nostrils alone, the result is more natural, but oftentimes, the width is part of the patient's complaint. In this case, we would perform some sort of nostril narrowing procedure," he says. However, this complicates the process — almost like adding an extra procedure, with the inherent risks. "There is some risk of nostril asymmetry, and there is the risk of a scar, but there has never in the history of medicine been keloid scarring in this area. So, fortunately, we can operate on this region with impunity," Dr. Hopping says.

ETHNIC BLENDING Interestingly, as surgeons familiarize themselves with the unique anatomical distinctions inherent in various ethnic groups, and as cosmetic surgery becomes more acceptable, the culture is morphing in a way that de-emphasizes these distinctions. The ideal "look" is one that's becoming interchangeable among races and ethnicities, according to Dr. Hopping.

"I see that things are changing. In the characters that we see on nightly television shows and elsewhere, ethnic blending is occurring," he says. "Everybody wants to de-emphasize their nose a little bit. The noses are getting more and more alike, and I believe this is a product of the overall ethnic blending occurring in our society."

This, he adds, is a new concept that cosmetic surgeons should be aware of as they counsel their patients.

Face simulation module allows sneak peek of results before surgery

Article-Face simulation module allows sneak peek of results before surgery

Key iconKey Points

  • Axis Three module allows patients, physicians to set realistic aesthetic goals prior to facial procedures
  • Physicians using software can more accurately control nuances of nose when planning rhinoplasty procedures
  • Virtual images can be altered, modified in just a few seconds

INTERNATIONAL REPORT — Innovative technological advances have given birth to Axis Three's Portrait Face Simulation Module, allowing patients to view a three-dimensional (3-D) simulation of what their aesthetic outcome will look like prior to the actual cosmetic procedure taking place. The technology benefits both physicians and patients, as realistic aesthetic goals can be discussed and agreed upon well before the first cut.

Using Axis Three's 3-D face simulation software, surgeons can improve the expectations and experiences of patients seeking surgical improvements to their nose, chin, cheeks and jaw.

The face simulation module is based on the same technology as Axis Three's Portrait 3D Surgical Simulation Platform, which shows patients who plan to undergo breast procedures a more accurate visualization of the surgical outcome prior to the surgery. Using a 3-D camera, the patient's image is captured, processed and displayed on a viewing screen. The captured images give a realistic representation of the body, and they can be rotated, altered and viewed from all angles.

"This technology is a major advantage, as it allows for a more constructive, precise and interactive discussion of what the patient's cosmetic goals are. The face module is particularly useful for cosmetic rhinoplasty procedures, chin augmentation or chin reduction, cheek augmentation, jaw contouring, and even neck contouring when planning a lipoplasty and reduction in the neck/jaw area," says Paul C. Zwiebel, M.D., D.M.D., F.A.C.S., Littleton, Colo.

Axis Three's technology differs from other, similar technologies in that its integrated physics engine can address and measure tissue characteristics such as tissue elasticity and density. In software terms, a mathematical model allows the skin elasticity and density to be profiled for each cosmetic patient individually.

RHINOPLASTY SIMULATION Compared to the breast module, the face module takes a softer approach, because there is more artistry involved in procedures such as rhinoplasty. Therefore, a "softer" software program was engineered, allowing the physician to more accurately control the fine nuances and sculpt the nose to the patient's specifications as they would in the operating room in real surgery time.

In the face simulation's rhinoplasty module, a series of landmark registration points are plotted in and around the nose. Within those points, the physician can move each of those regions to fit a nose that the patient would aesthetically desire post-procedure. The physician can profile backward and forward, widening or narrowing the nostrils and other physical aspects until the desired image is achieved.


Comparison screens such as these enable users to view all of a patient's case data together. Users can show pre-op images beside simulated views. (Photos credit: Axis Three)
"The software can even measure parameters such as volume, which is otherwise very difficult to measure and quantify without such technology in a real-world circumstance," says Paul Moffett, director of engineering at Axis Three, Belfast, Northern Ireland. "Getting a true volume calculation can help the surgeon better plan together with the patient just exactly what the aesthetic result should look like."

CONSULTATION COUNTS Most surgeons would agree that the essence of the consultation is communication. This is where the patient communicates goals and desires and the surgeon communicates what he or she thinks can be realistically achieved. The Axis Three face module represents a language that both patient and physician speak — namely, visual imaging.


Screen shot of the user interface showing the rhinoplasty toolbar, which allows control over the projection of the nose. (Photo credit: Axis Three)
"As a communication tool, imaging has been a fantastic advance, and being able to view images in 3-D as opposed to 2-D is a huge step forward. The patient not only feels much more comfortable that their doctor understands what it is that they want to achieve, but also can feel more confidence that they are not going to have a surprise when they wake up from surgery," Dr. Zwiebel says.

SCANNER ADDITION Recently, Axis Three introduced its XS-200 scanner, which captures anatomically accurate 3-D images of a patient's face in order to simulate surgery outcomes. This tool complements Axis Three's face simulation software module and allows surgeons to even more accurately showcase aesthetic surgical outcomes prior to the surgical procedure itself.

The XS-200 scanner is a mountable unit optimized to capture the face topology with a minimal hardware footprint and serves as a vehicle for delivering Axis Three's simulation software. The scanner attaches directly to the USB port of a surgeon's computer.

IMAGE PROCESSING Another advantage to the Axis Three simulation technology is the efficiency and speed at which images are processed. Virtual images can be altered and modified in only a few seconds.

"Many patients will see more than one doctor for consultation before they have a procedure done. My patients have commented explicitly on how tremendously helpful the 3-D imaging was in their decision process. Axis Three's technology has had a dramatic effect on my consultation and increased our patient flow for breast augmentation. I suspect that the 3-D imaging for face procedures will have a similar impact," Dr. Zwiebel says.

Of course, realizing the final cosmetic outcome close to the 3-D image pre-surgery has much to do with the skill and experience of the surgeon, the wound-healing quality of the patient's tissues and the type of procedure performed. However, according to Dr. Zwiebel, the surgeon's judgment in portraying an accurate image as opposed to getting creative and showing something that is impossible to do still remains the fundamental basis for the validity of the tool.

NEXT PHASES Axis Three's next project will concentrate on the top layer of the skin, focusing on the removal of wrinkles and skin tightening. According to Mr. Moffett, this is a state-of-the-art technology that offers a high-tech angle to cosmetic procedures, while adding an element of assurance to the patient.

"As we're bombarded with new technologies targeting cosmetic surgery, we always have to be discriminating and diligent. In this particular instance, this technology clearly is an advance, easy to embrace and intuitive," Dr. Zwiebel says.

Disclosures:
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Laser treatments on darker skin tones effective with conservative approach

Article-Laser treatments on darker skin tones effective with conservative approach

Key iconKey Points

  • Increased pigment content in ethnic patients' skin absorbs laser energy in deeper targets
  • Laser epilation treatments less effective in patients with skin of color
  • Asian skin tends to have delay in terms of photoaging compared to Caucasian skin

Cutaneous laser therapy can prove to be challenging in treating patients with skin of color, as this patient population has a higher risk of unwanted cosmetic side effects following treatment. A cautious and conservative approach and use of the right laser device can be instrumental in helping to avert unwanted side effects from laser therapy.


Dr. Chan
PIGMENT-RELATED CHALLENGES Compared to Caucasian skin, Asian, Latino, Middle Eastern and black patients' skin have a higher content of epidermal melanin, resulting in darker, more pigmented skin tones. This higher melanin content presents potential problems when these patients undergo cutaneous laser treatments, such as for telangiectasias and epilation.

"The increased melanin can potentially pose a greater risk of complications when undergoing cutaneous laser treatments, because the pigment can absorb the laser energy, leading to undesirable side effects, the most common of which being postinflammatory hyperpigmentation," says Henry Chan, M.D., Ph.D., F.R.C.P., F.H.K.C.P., F.H.K.A.M., honorary professor, Li Ka Shing Faculty of Medicine, University of Hong Kong, HKSAR, and visiting scientist, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston.

According to Dr. Chan, the increased pigment content in the epidermis also absorbs some of the laser energy that one may want to use in deeper targets, such as the hair follicles in hair-removal procedures. When performing laser epilation, a cooling device is regularly used to protect the epidermis from the energy delivered down to the pigment cells around the hair follicle. However, due to the greater epidermal melanin content in patients with skin of color, the laser energy is more readily absorbed, reducing the efficacy of such laser treatments.

"Though an effective cooling is extremely important during and after the laser treatment, laser epilation treatments are less effective in patients with skin of color and are associated with a greater potential for complications," Dr. Chan says.

A similar problem is encountered when using lasers for the treatment of telangiectasias, as the melanin absorption of laser energy light sources has a very wide range. Therefore, lasers cannot only be less effective in the treatment of telangiectasias in patients with skin of color, but postinflammatory hyperpigmentation can also result, as well as interference by the superficial pigment in the epidermis, ultimately reducing the efficacy of the laser treatment.

POSSIBLE SOLUTIONS In order to avoid the unwanted side effects of laser treatments in patients with skin of color, it is very important to choose the proper parameters of the chosen laser device. It's also critical to apply adequate cooling during and after the laser procedure and to be less aggressive when performing therapy, particularly in higher-risk patients.

Devices such as Q-switched lasers are very effective in the removal of lentigines and freckles among Caucasians and Asians, but there is a 10 percent risk of postinflammatory hyperpigmentation in Asian skin. Therefore, these lasers can be less optimal for this indication in darker-skinned patients, and long-pulsed lasers may prove to be the better choice.

"Long-pulsed lasers are gentler than Q-switched lasers, because the Q-switched lasers induce not only a photothermal effect, but also the rapid change in the thermal gradient can lead to photomechanical damage, where the energy is delivered so rapidly that it literally causes the cells to rupture. Such damage can cause a greater risk of postinflammatory hyperpigmentation among skin of color," Dr. Chan explains.

Long-pulsed lasers are more effective mainly because they heat up the target more gradually and gently, reducing the excessive degree of inflammation and therefore decreasing the chance of adverse events. In order to maximize aesthetic outcomes and goals, more frequent treatment sessions would be required with this laser.

IPL AND FRACTIONAL DEVICES Intense pulsed light (IPL) is also effective for various cosmetic indications, even though the device is less selective in targeting specific lesions. According to Dr. Chan, IPL devices can work well depending on the contrast of the patient's skin in respect to the target lesions such as lentigines and freckles. IPL treatment is very effective and carries a low risk of adverse events if the patient's skin color is in great contrast with the color of targeted lesions. However, where the degree of contrast between the targeted lesions and the surrounding skin is much less, there will be a greater risk of injury.

"Either you use too low an energy not to negatively impact the surrounding skin, resulting in less-optimal treatment results, or too high an energy to effectively address the target lesions, with the increased risk of damaging the surrounding skin, leading to unwanted side effects. Therefore, one has to be extremely careful when treating patients with skin of color where the contrast between lesion and surrounding skin is low," Dr. Chan says.

Fractional resurfacing is frequently used for skin rejuvenation in Asian skin. However, given the fact that the degree and severity of photoaging tends to be much less in patients of skin of color, the role of these more aggressive ablative procedures (which carry a higher risk of complications) is much less justifiable, Dr. Chan says.

Noninvasive procedures such as radiofrequency and focus ultrasound for skin tightening are effective and very popular, as is nonablative skin rejuvenation using nonablative fractional resurfacing or nonablative laser devices.

LESS PHOTOAGING Compared to Caucasian skin, Asian skin tends to have much delay in terms of photoaging. Pigmentary issues such as lentigines, freckles and melasma are common problems after extensive ultraviolet (UV) light exposure, but, compared to Caucasian skin, deep wrinkles tend to present one to two decades later.

"The superficial epidermal melanin content in Asians is higher and therefore offers a greater UV protection — approximately 10 times that of Caucasian skin — and this protection increases with darker skin," Dr. Chan says. "As the degree and speed of skin aging is not as severe as that seen in Caucasian skin, we tend not to require extremely dramatic means to rejuvenate the skin."

For those physicians who do not regularly see patients with skin of color, Dr. Chan suggests that they treat a small test area of lesional skin with a given device first, and establish the correct parameters of the laser treatment in each patient before treating all lesions. Additionally, physicians with less experience with laser treatments in skin of color may want to begin with more forgiving devices, such as the long-pulsed laser.

"Remember to be conservative when performing laser procedures in skin of color. You do not want a patient to return because of potential issues and adverse events," Dr. Chan says.

DISCLOSURES:

Chemical peels in skin of color effective with post-treatment compliance

Article-Chemical peels in skin of color effective with post-treatment compliance

Key iconKey Points

  • In performing chemical peels on dark-skinned patients, products containing salicylic acid induces less inflammation and treats acne
  • Post-peel hyperpigmentation more obvious in skin of color
  • Consistent sunblock use crucial following chemical peel treatment

Skin that produces a lot of melanin has an increased reaction to influences such as sun exposure and heat, as well as anything else that can potentially irritate the skin, such as a chemical peel. Chemical


Dr. Bucay
peels are as safe and effective in darker-skinned people as in their light-skinned counterparts, but underestimating the potential for adverse events such as post-peel hyperpigmentation can be short-sighted, says Texas dermatologist Vivian Bucay, M.D.

"Generally speaking, the darker skin types tend to have more of a tendency to react to anything that would irritate the skin — anywhere from a mosquito bite to a topical numbing agent to a burn on the stove to a chemical peel," says Dr. Bucay. When a dark-skinned patient presents and either requests or is a candidate for a chemical peel, she analyzes the patient's goals and carefully reviews the medical history. "We need to know if this is somebody who is getting a chemical peel for acne or for melasma or for something else, and I also look to see if they have any history of sensitivity to irritants or a history of eczema or rosacea," Dr. Bucay says.


Dr. Downie
Armed with this information, Dr. Bucay chooses the appropriate agents accordingly. "For a dark-skinned patient who is seeking a chemical peel for melasma or acne, I would use a product containing salicylic acid, because it does not induce a lot of inflammation and is very good for redistributing pigment granules, but would also take care of acne breakouts," she says. Glycolic acid, she points out, would be too irritating to somebody of darker skin type with sensitive skin and could result in a postinflammatory hyperpigmentation.

SUPERFICIAL TREATMENT New Jersey dermatologist Jeanine Downie, M.D., also stresses the importance of choosing a more superficial peel. "In a situation like this, you should definitely go with a lighter, more superficial peel in the 20 percent, 25 percent or 30 percent range," she says, adding that it's a good idea to "avoid medium-depth peels (in this patient population) until you have significant experience and really know what you're doing."


A patient burned with a curling iron and suffering from melasma is shown before treatment (left) and two months later, after two salicylic acid peels, 20 percent, and one Fraxel re:store treatment. (Photos credit: Jeanine Downie, M.D.)
When performed correctly, chemical peels offer patients of color striking benefits, according to Dr. Downie. "In my African- American patients, if I do the peel close to the lower lid rim of their eyes and they see that their dark circles are fading, they are very appreciative," she says. "African Americans tend to age with patchy dyspigmentation, and my patients of color really enjoy the overall enhancement of their skin tone."

Regarding hyperpigmentation, "People with skin of color are often coming into the office to get help with their hyperpigmentation problems, so you certainly don't want to add to that," Dr. Downie says. Post-peel hyperpigmentation does not happen frequently, she notes, but when it does, it can be troublesome for the patient and the physician. "If the patient's skin is overly sensitive, if you leave the peel on too long or it doesn't get rinsed off (thoroughly), the result can be the induction or worsening of hyperpigmentation," she says.

Post-peel hyperpigmentation is possible in anyone, but is more obvious in skin of color. "If a physician does not have a lot of experience performing chemical peels in patients of color, they should feel comfortable referring the patient elsewhere," Dr. Downie says.

PRETREATMENT OPTIONS Dr. Bucay suggests that inhibiting pigment production before the procedure can reduce a possible inflammatory response to the chemical peel. Starting patients on hydroquinone and/or topical vitamin C six weeks before the chemical peel would be ideal, she says, stressing that even if the patient pre-loads for two weeks prior to the peel, there could be benefits.

Of course, the most important factor in the process is consistent sunblock use. "The patient must wear sunblock from the moment they leave the office, because all it takes is one sun exposure, especially after a peel, and they will pigment quickly," Dr. Downie says. Dr. Bucay says she prefers a physical as opposed to chemical sunblock, such as a micronized preparation of transparent zinc oxide or titanium dioxide. "A physical sunblock reflects the light and is less likely to cause irritation of the skin afterward," she says.

Poor candidates for chemical peels, especially in darker-skinned patients, are those who are not consistent in their use of sunblock and those who have a tendency to pick their skin. "They're going to tell you their skin isn't any better, but it's not because of your treatment plan, it's because they're not committed to the post-peel instructions," Dr. Downie says. "The bottom line is that most people are good peel candidates if they need a deeper level of exfoliation and if they follow our instructions."

In the case of a chemical peel gone wrong, Dr. Downie recommends several options for repairing the post-peel hyperpigmentation: Re-peel the patient with a lighter peel, advise the patient to wear sunscreen and reapply it more frequently, or suggest a gentle fade cream. Among the available prescription fade creams, Dr. Downie says she likes EpiQuin Micro (hydroquinone USP 4 percent, SkinMedica) and Tri-Luma (fluocinolone acetonide 0.01 percent, hydroquinone 4 percent, tretinoin 0.05 percent, Galderma).

DISCLOSURES:

Long-pulsed lasers, small spot size reduces lentigine treatment risks in Asian skin

Article-Long-pulsed lasers, small spot size reduces lentigine treatment risks in Asian skin

Key iconKey Points

  • Retrospective study compared outcomes of treatment with four pigment-specific lasers to treat freckles and lentigines in Asian patients
  • Risk of postinflammatory hyperpigmentation in skin of color higher when using Q-switched versus long-pulsed laser

Dr. Chan
Results of a retrospective study comparing outcomes using four different pigment-specific lasers to treat freckles and lentigines in Asian patients are consistent with principles of cutaneous laser surgery. They also underscore the importance of considering both the pulse duration and laser spot size to optimize the benefit-to-risk ratio when treating these benign melanocytic lesions in darker skin, according to researchers at the 2010 annual conference of the American Society for Laser Medicine & Surgery.

The study identified 40 Chinese patients with Fitzpatrick skin types III or IV who were treated with either a 595 nm long-pulsed dye laser (LPDL; Vbeam Perfecta, Candela), a 755 nm LP alexandrite laser (GentleLASE, Candela), a 532 nm Q-switched (QS) Nd:YAG laser (MedLite C3, HOYA ConBio) or a 532 nm LP KTP laser (Gemini, Iridex). The patients were randomly selected from a large cohort of patients treated by Henry Chan, M.D., Ph.D., F.R.C.P., F.H.K.C.P., F.H.K.A.M., honorary professor, Li Ka Shing Faculty of Medicine, University of Hong Kong, HKSAR, and visiting scientist, Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston.

Patients received between one and four treatments at intervals of four to six weeks. The number of treatments depended on lesion response, and the mean for the entire study population was 1.8. An independent dermatologist assessed pigmentation clearance and postinflammatory hyperpigmentation (PIH) through visual analogue scale grading of pre- and post-treatment photographs.

PIH, SIGNIFICANT RESULTS Statistically significant improvement of both global and focal facial pigmentation was achieved in patients treated with the 595 nm LPDL, 532 nm QS Nd:YAG and 532 nm LP KTP lasers. The 755 nm LP alexandrite laser failed to produce statistically significant improvement and was also associated with the highest incidence of PIH (38 percent). The risk of PIH was also relatively high following treatment with the 532 nm QS Nd:YAG laser (22 percent), was small in the 595 nm LPDL group (6 percent) and absent after treatment with the 532 nm LP KTP laser.

"As a retrospective review, this study has methodological limitations, the most important of which is potential selection bias, as patients with a poorer clinical response or who developed a complication may be more likely to return for follow-up care than those who had an excellent outcome," Dr. Chan says.


Dr. Ho
"Nevertheless, the findings are consistent with the results of a prospective, randomized, split-face study we published that showed a long-pulsed 532 nm Nd:YAG laser was gentler than a QS 532 nm Nd:YAG laser when treating skin of color (Dermatol Surg. 2000;26:743-749). However, spot size is also important, since with a larger spot size, there is a risk of laser energy absorption by both the targeted melanocytic lesion and darker-pigmented, normal surrounding skin," Dr. Chan says.

Stephanie G.Y. Ho, M.D., honorary clinical research associate, University of Hong Kong, presented the research at the meeting. She says, "There has been little research comparing different pigment-specific lasers for darker skin types. Our study highlights the importance of using long-pulsed lasers, smaller spot sizes and cooling strategies in order to minimize the risk of PIH during laser treatment for skin of color. In addition, the 595 nm LPDL and 532 nm LP KTP, which appeared to be safe and effective for lentigines in darker skin types, may also be used to treat other conditions, and therefore may be good cost- and space-saving solutions for clinicians."

PIH RISKS FOR EACH LASER Dr. Chan explains that while all of the lasers used are effective for treating lentigines and freckles, complications are a particular concern in Asian patients because of the higher epidermal melanin content of their darker skin. The risk of PIH in skin of color is higher when using a QS versus LP laser because the QS device, with its relatively short pulse duration (nanoseconds), causes photomechanical injury in addition to a therapeutic photothermal effect.

"With the nanosecond pulse duration, there is a rapid change in the thermal gradient of the target that generates an ultrasonic wave and subsequently photomechanical injury leading to inflammation," Dr. Chan says. "The millisecond pulse duration of the LP lasers more closely matches the thermal relaxation time of the epidermal basal layer. It is more gentle because it produces only a photothermal effect, without inducing rapid thermal expansion that can lead to an ultrasonic wave."

Despite its long pulse duration, the LP alexandrite had the highest risk of PIH among the four lasers included in the study. This association may be explained by the large, 10 mm spot size of the device used.

"Spot size is not a major issue if there is significant contrast in pigmentation between the target lesion and surrounding normal skin," Dr. Chan says. "However, in darker Asian skin, the difference in pigmentation is less. Therefore, laser energy is also absorbed by the surrounding normal skin, which can lead to injury and an increased risk of complications."

Both the 532 nm QS Nd:YAG and the 532 nm LP KTP lasers have only a 2 mm spot size so that they selectively target smaller freckles and lentigines. In addition, the 532 nm LP KTP laser has a cooling device that helps protect normal surrounding skin.

Although the 595 nm LPDL has a relatively large, 7 mm spot size, the device used also features a compression handpiece that empties blood from vessels in the underlying skin, reducing the risk of purpura and therefore PIH, as well.

"Even with its larger spot size, the 595 nm LPDL will only affect the target lesion if it is used to treat larger lentigos. However, hyperpigmentation can also develop through induction of purpura secondary to mechanical injury to blood vessels. If bruising occurs, there can be some hemosiderin deposition that appears as PIH," Dr. Chan says.

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